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In June 2011, FHM in Spain ranked her 11th on the "Las 100 mujeres más sexys del mundo list.
Lopilato joined the cast of the El Trece series Lobo as a villainess, opposite Ana Linares's character (Vanesa González).
Lopilato made her debut in the television series Mi familia es un dibujo in 1995, and continued working as a child model. She reprised her role of Luisana Maza in Chiquititas, la historia, a mini–series broadcast in 2001, and Chiquititas: Rincón de Luz, a 2001 Chiquititas spin–off film.
In 1999, she was chosen to play Luisana Maza in Chiquititas, a popular television series created by Cris Morena. In 2000, she appeared in the film Un Amor en Moises Ville.
Relationship with him also didn’t last for long and they broke up in 2006.
Then she was in a relationship with Juan Monaco in 2006 which ended in 2008.
In 2014, she finished her work as the face of Ultimo.
She appeared in several commercials in Argentina and Israel.
In 2013, she played a young cancer victim in the second season of the Argentine remake of In Treatment, En terapia, starring Diego Peretti and broadcast by TV Publica.Lopilato began her career as a singer in the TV series that launched her to fame, Chiquititas.In 2000, she participated in the album with other actors from the series.The series generated another band which released two albums that received gold certification in Argentina.Lopilato was the face of the underwear brand Promesse from 2006-10.